Why sequence the entire human genome when the 30,000 genes of the coding region tell us 95% of the biology? That’s another angle to atttain the $10 personal genome sooner. Johathon Rothberg and his associates at 454 Life Sciences keep coming up with good ideas:
…But the Methuselah effort will use a new, streamlined way of analyzing the genome by isolating and sequencing only the so-called coding regions of DNA. By focusing on this small portion of the genome–about 1 percent–scientists can sequence 100 genomes for the same price as sequencing Watson’s entire genome.
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